金山贵宾会,金山贵宾会登录

医学部坐倚珞珈山,环绕东湖水,绿树成荫,花香流溢。学部源于1943年成立的湖北省省立医学院,现在是金山贵宾会六大学部之一。 学部含基础医学院、第一临床学院、第二临床学院、口腔医学院、药学院、健康学院、职业技术学院...

地址: 湖北省武汉市武昌区东湖路115号
电话:027-68759364
中国科学院院士: 邓子新舒红兵
国家级教学名师: 樊明文边专
国家杰出青年基金获得者: 邓子新舒红兵章晓联李红良卿国良
百千万人才工程选者: 舒红兵、黄从新章晓联?
万人计划: 领军人才:舒红兵唐其柱李红良 ? 青年拔尖人才: 刘天罡?、
王连荣王培刚 ? ? ? ? ?
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教育部新世纪优秀人才: 章晓联、何小华乐江、 于红刚 李雁郑芳、
胡锦跃、 黄鹤、李红良、 张 旗、 叶晓茜、 尚政军、 郭继华、 张玉峰、
周海兵、 刘天罡、 王连荣、 瞿旭东、洪 葵

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姓名:李红良

单位:金山贵宾会基础医学院

职称:院长、教授、博导

邮箱:lihl@whu.edu.cn

联系电话:027-68759302

研究方向:

1.心血管代谢性疾病的发生机制与防治;研究免疫机制、信号传导通路在心血管代谢性疾病发生发展中的作用及其机制。

2.生物医学工程:基因敲除及转基因动物模型的构建。

 








代表性论著:

1.Zhao GN, Zhang P, Gong J, Zhang XJ, Wang PX, Jiang Z, Shen LJ, Ji YX, Tong JJ, Wang YT, Wei QF, Wang Y, Zhu XY, Zhang X, Fang J, She ZG, Wang ZH, Huang Z, Li H*, TMBIM1 protects against nonalcoholic steatohepatitis in mice and monkeys by targeting TLR4 for lysosomal degradation, Nat Med., 2017 ;23(6):742-752.

2.Wang PX, Ji YX, Zhang XJ, Zhao LP, Yan ZZ, Zhang P, Shen LJ, Yang X, Fang J, Tian S, Zhu XY, Gong J, Zhang X, Wei QF, Wang Y, Li J, Wan L, Xie QG, She ZG, Wang ZH, Huang Z, Li H*, Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates, Nat Med.2017;23(4):439-449.

3.Wang ZH, Zhang XJ, Zhang P, Wang XH, Chen I, Gao C, Deng KQ, Gong J, Yokota T, Wang H, Cass A, Ren SX, Vondriska T, Li GP, Yang HT, Xiao XS, Li H*, Wang Y*, A long non- coding RNA defines an epigenetic check point for cardiac hypertrophy. Nat Med. 2016 ,22(10):1131-1139.

4.Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, Zhao G, Zhu X, Zhang Y, Yang S and Li H*. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016; 7:10592.

5.Ji Y, Zhang P, Zhang X, Zhao Y, Deng K, Jiang X, Wang P, Huang Z and Li H*. The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. Nat Commun. 2016; 7:11267.

6.Deng K, Wang A, Ji Y, Zhang X, Fang J, Zhang Y, Zhang P, Jiang X, Gao L, Zhu X, Zhao Y, Gao L, Yang Q, Zhu X, Wei X, Pu J and Li H*. Suppressor of IKK? is an essential negative regulator of pathological cardiac hypertrophy. Nat Commun. 2016; 7:11432.

7.Zhang S, Zhu L, Chen H, Zhang R, Zhang P, Jiang D, Gao L, Tian S, Wang L, Zhang Y, Wang P, Zhang X, Zhang X, Liu D and Li H*. Interferon regulatory factor 9 is critical for neointima formation following vascular injury. Nat Commun. 2014; 5:5160.

8.Jiang D, Wei X, Zhang X, Liu Y, Zhang Y, Chen K, Gao L, Zhou H, Zhu X, Liu PP, Bond Lau W, Ma X, Zou Y, Zhang X, Fan G and Li H*. IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurinsignalling. Nat Commun. 2014; 5:3303.

9.Lu Y, Li Z, Jiang D, Wang L, Zhang Y, Chen K, Zhang X, Liu Y, Fan G, Chen Y, Yang Q, Zhou Y, Zhang X, Liu D and Li H*. TRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death. Nat Commun. 2013; 4:2852.

10.Xiang M, Wang P, Wang A, Zhang X, Zhang Y, Zhang P, Mei F, Chen M and Li H*. Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis. J Hepatol. 2016; 64:1365-1377.

11.Hu J, Zhu X, Zhang X, Wang P, Zhang R, Zhang P, Zhao G, Gao L, Zhang X, Tian S and Li H*. Targeting TRAF3 signaling protects against hepatic ischemia/reperfusions injury. J Hepatol. 2016; 64:146-159.

12.Gao L, Wang P, Zhang Y, Yu C, Ji Y, Wang X, Zhang P, Jiang X, Jin H, Huang Z, Zhang Z and Li H*. Tumor necrosis factor receptor-associated factor 5 (Traf5) acts as an essential negative regulator of hepatic steatosis. J Hepatol. 2016;65:125-36.

13.Wang P, Zhang R, Huang L, Zhu L, Jiang D, Chen H, Zhang Y, Tian S, Zhang X, Zhang X, Liu D and Li H*. Interferon regulatory factor 9 is a key mediator of hepatic ischemia/reperfusion injury. J Hepatol. 2015; 62:111-120.

14.Zhu L, Wang A, Luo P, Wang X, Jiang D, Deng W, Zhang X, Wang T, Liu Y, Gao L, Zhang S, Zhang X, Zhang J and Li H*. Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor α in mice. J Hepatol. 2014; 60:1046-1054.

15.Yan FJ, Zhang XJ, Wang WX, Ji YX, Wang PX, Yang Y, Gong J, Shen LJ, Zhu XY, Huang Z, Li H*. The E3 ligase TRIM8 targets TAK1 to promote insulin resistance and steatohepatitis. Hepatology. 2017;65(5):1492-1511.

16.Wang X, Zhang R, She Z, Zhang X, Jiang D, Wang T, Gao L, Deng W, Zhang S, Zhu L, Guo S, Chen K, Zhang X, Liu D and Li H*. Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance. Hepatology. 2014; 59:870-885.

17.Zhang Y, Zhang XJ, Wang PX, Zhang P, Li H*.Reprogramming Innate Immune Signaling in Cardiometabolic Disease. Hypertension. 2017;69(5):747-760.

18.Zhu X, Fang J, Gong J, Guo J, Zhao G, Ji Y, Liu H, Wei X and Li H*. Cardiac-Specific EPI64C Blunts Pressure Overload–Induced Cardiac HypertrophyNovelty and Significance. Hypertension. 2016; 67:866-877.

19.Gong J, Li Z, Guo S, Zhang X, Zhang P, Zhao G, Gao L, Zhang Y, Zheng A, Zhang X, Xiang M and Li H*. Neuron-Specific Tumor Necrosis Factor Receptor–Associated Factor 3 Is a Central Regulator of Neuronal Death in Acute Ischemic Stroke Hypertension. 2015; 66:604-616.

20.Zhang X, Zhang P and Li H*. Interferon Regulatory Factor Signalings in Cardiometabolic Diseases. Hypertension. 2015; 66:222-247.


友情链接
教育部 国家卫生健康委员会 省教育厅 省卫生健康委 金山贵宾会 校图书馆
基础医学院 第一临床学院(人民医院) 第二临床学院(中南医院) 口腔医学院(口腔医院) 药学院 健康学院 医学研究院 医学职业技术学院 动物实验中心和ABSL-Ⅲ实验室 亚心临床学院(亚洲心脏病医院) 同仁临床学院(同仁医院) 武汉总医院临床学院(广州军区武汉总医院) 恩施临床学院(恩施州中心医院) 医学部附属中山医院
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